【English Synonyms】

【Description】

Mito Tracker Deep Red FM is a red fluorescent dye that can selectively accumulate in the mitochondrial matrix.

【References】

Buckman JF, et al. MitoTracker labeling in primary neuronal and astrocytic cultures: influence of mitochondrial membrane potential and oxidants. J Neurosci Methods. 2001 Jan 15;104(2):165-76.

【English Synonyms】

2-((1E,3E)-5-((E)-3,3-dimethyl-1-octadecylindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-1-octadecyl-3H-indol-1-ium iodide

【Description】

DiD dye is a lipophilic fluorescent dye, which is mainly used to stain cell membranes and other fat-soluble biological structures.

【References】

Meng Li, et al. In Vivo Tracking of Human Adipose-derived Mesenchymal Stem Cells in a Rat Knee Osteoarthritis Model with Fluorescent Lipophilic Membrane Dye. J Vis Exp. 2017; (128): 56273.

【English Synonyms】

1,1,3-trimethyl-2-((1E,3E,5E)-5-(1,1,3-trimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)penta-1,3-dien-1-yl)-1H-benzo[e]indol-3-ium iodide

【Description】

IR-676 is a cyanine dye with an absorption wavelength of nearly 680 nm.

【References】

Hydrophobic cyanine dye-doped micelles for optical in vivo imaging of plasma leakage and vascular disruption.Journal of Biomedical Optics ( IF 3.0 ) Pub Date : 2015-01-30 , DOI: 10.1117/1.jbo.20.1.016022 Bálint Botz 1 , Kata Bölcskei 1 , Ágnes Kemény 1 , Zoltán Sándor 2 , Valéria Tékus 1 , György Sétáló 3 , Janka Csepregi 4 , Attila Mócsai 4 , Erika Pintér 1 , László Kollár 5 , Zsuzsanna Helyes 1.

【English Synonyms】

2-((E)-2-((E)-2-chloro-3-(2-((E)-1,3,3-trimethylindolin-2-ylidene)ethylidene)cyclopent-1-en-1-yl)vinyl)-1,3,3-trimethyl-3H-indol-1-ium iodide

【Description】

IR-797 chloride is a near-infrared ( NIR ) dye. The maximum absorption wavelength of IR 797 is close to 700 nm. IR-797 shows some aggregation-induced emission ( AIE ) properties.

【References】

Fan Cao, et al. Wavelength-Dependent Tip-Enhanced Laser Ablation of Organic Dyes. The Journal of Physical Chemistry C. 2020, 124, 3, 1918–1922.

【English Synonyms】

(E)-2-(4-hydroxy-3,5-diiodostyryl)-1,1-dimethyl-3-(4-((2-((4-methylphenyl)sulfonamido)ethyl)carbamoyl)benzyl)-1H-benzo[e]indol-3-ium bromide.

【Description】

ER-ZS can diagnose nonalcoholic fatty liver disease ( NAFLD ) by liver imaging based on high ER stress. ER-ZS is a type I photosensitizer that can produce O2 under light conditions. Photodynamic therapy causes severe oxidative damage to the endoplasmic re

【References】

ZENG S, WANG Y, CHEN C, et al. An ER-targeted, Viscosity-sensitive Hemicyanine Dye for the Diagnosis of Nonalcoholic Fatty Liver and Photodynamic Cancer Therapy by Activating Pyroptosis Pathway [J]. Angew Chem Int Ed Engl, 2024, 63(9): e202316487. https://doi.org/10.1002/anie.202316487.

【English Synonyms】

methyl 2-(6-acetoxy-7-chloro-4-((E)-2-((Z)-4-cyano-5-(cyano(isocyano)methylene)-2,2-dimethyl-2,5-dihydrofuran-3-yl)vinyl)-2,3-dihydro-1H-xanthen-1-yl)benzoate.

【Description】

NCES is used to guide liver cancer surgery through high-contrast in vivo imaging and to detect clinical serum samples from patients with liver cancer. NCES has great potential in drug development, medical diagnostic imaging applications, and early detecti

【References】

JIANG R, XIA Y, LIU Q, et al. Carboxylesterase-activated near-infrared fluorescence probe for highly sensitive imaging of liver tumors [J]. Journal of Materials Chemistry B, 2024, 12(6): 1530-7. https://doi.org/10.1039/D3TB02759G.

【English Synonyms】

(E)-2-bromo-4-(2-(3-(dicyanomethylene)-5,5-dimethylcyclohex-1-en-1-yl)vinyl)phenyl isonicotinate.

【Description】

DCI-Br-3 is a fast, highly sensitive and selective probe for the detection of epileptic brain thiols, which can effectively pass through the blood-brain barrier and help to monitor the decrease of thiol content in the brain.

【References】

YANG Y, ZHANG Y, MA M, et al. Synergistic Modulation by Halogens and Pyridine Crossing the Blood–Brain Barrier for In Situ Visualization of Thiol Flux in the Epileptic Brain [J]. Analytical Chemistry, 2022, 94(41): 14443-52. https://doi.org/10.1021/acs.analchem.2c03390.

【English Synonyms】

(E)-4-(3-(benzo[d]thiazol-2-yl)-2-(2,4-dinitrophenoxy)-5-methylstyryl)-1-butylpyridin-1-ium chloride

【Description】

HBTP-H2S ( chloride ) is a near-infrared fluorescent probe for in situ bioimaging of endogenous H2S in rice roots under aluminum stress and waterlogging stress.

【References】

WANG J, XIE H, LI H, et al. NIR Fluorescent Probe for In Situ Bioimaging of Endogenous H2S in Rice Roots under Al3+ and Flooding Stresses [J]. Journal of Agricultural and Food Chemistry, 2021, 69(47): 14330-9. https://doi.org/10.1021/acs.jafc.1c05247.

【English Synonyms】

(E)-9-(2-carboxyphenyl)-6-(2-(4-nitrophenyl)-2-oxoacetamido)-4-(2-((Z)-1,3,3-trimethylindolin-2-ylidene)ethylidene)-1,2,3,4-tetrahydroxanthylium.

【Description】

NIR-LAP can sensitively and accurately monitor peroxynitrite ( ONOO- ) ( detection limit : 90 nM ), thereby accurately assessing drug-induced hepatotoxicity.

【References】

CHENG D, PENG J, LV Y, et al. De Novo Design of Chemical Stability Near-Infrared Molecular Probes for High-Fidelity Hepatotoxicity Evaluation In Vivo [J]. Journal of the American Chemical Society, 2019, 141(15): 6352-61. https://doi.org/10.1021/jacs.9b01374.

【English Synonyms】

(E)-6-(2-amino-4-methylpentanamido)-9-(2-carboxyphenyl)-4-(2-((Z)-1,3,3-trimethylindolin-2-ylidene)ethylidene)-1,2,3,4-tetrahydroxanthylium.

【Description】

NIR-LAP can sensitively and accurately monitor leucine peptidase ( detection limit : 80 mU / L ), thereby accurately assessing drug-induced hepatotoxicity.

【References】

CHENG D, PENG J, LV Y, et al. De Novo Design of Chemical Stability Near-Infrared Molecular Probes for High-Fidelity Hepatotoxicity Evaluation In Vivo [J]. Journal of the American Chemical Society, 2019, 141(15): 6352-61. https://doi.org/10.1021/jacs.9b01374.

【English Synonyms】

(E)-7-iodo-1,1,3-trimethyl-2-(2-(1-methyl-9-(2-morpholinoethyl)-9H-pyrido[3,4-b]indol-3-yl)vinyl)-1H-benzo[e]indol-3-ium iodide.

【Description】

TME-HYM is a new fluorescent probe based on the activation of acidic tumor microenvironment. TME-HYM ( PH Probe ) can selectively light cancer cells and tumor tissues. It has dual tumor selectivity and can accurately display tumor masses. HYM can achieve

【References】

XU Z, TAO W, QIAN J, et al. Dual Tumor-Selective β-Carboline-Based Fluorescent Probe for High-Contrast/Rapid Diagnosis of Clinical Tumor Tissues [J]. Molecular Pharmaceutics, 2024, 21(1): 152-63. https://doi.org/10.1021/acs.molpharmaceut.3c00689.

【English Synonyms】

1-(6-((4-carboxy-1-(2-((1-carboxy-4-((4-((3-(1-((2-(3,6-di(indolin-1-yl)xanthylium-9-yl)phenyl)sulfonyl)piperidine-4-carboxamido)propyl)carbamoyl)-2,6-dimethylbenzoyl)oxy)-3-oxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxobutan-2-yl)amino)-6-oxohexyl)-2-((1E,3E)-5-((Z)-1-ethyl-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-5-sulfonate.

【Description】

The LE 28 probe is highly selective for legumain, and legumain is found to be highly correlated with macrophage activation by LE 28 probe, and it is an ideal marker for primary tumor inflammation and early metastatic lesions.

【References】

EDGINGTON L E, VERDOES M, ORTEGA A, et al. Functional Imaging of Legumain in Cancer Using a New Quenched Activity-Based Probe [J]. Journal of the American Chemical Society, 2013, 135(1): 174-82. https://doi.org/10.1021/ja307083b.

【English Synonyms】

2-((1E,3E,5E)-5-(3-ethyl-1,1-dimethyl-6,8-disulfo-1,3-dihydro-2H-benzo[e]indol-2-ylidene)penta-1,3-dien-1-yl)-3-(1-(3-fluoro-5-(6,7,10-trimethoxy-4-oxo-4H-benzo[h]chromen-2-yl)phenoxy)-13-oxo-3,6,9-trioxa-12-azaoctadecan-18-yl)-1,1-dimethyl-8-sulfo-1H-benzo[e]indol-3-ium-6-sulfonate.

【Description】

CYP1B1-IN-6 is a fluorescent probe that can inhibit the activity of CYP1B1 and can be enriched in tumor cells by binding to CYP1B1. CYP1B1-IN-6 can identify tumor sites in fluorescence imaging and photoacoustic imaging modes.

【References】

CHEN D, LI R, SHAO Q, et al. Design and Synthesis of Novel Near-Infrared Fluorescence Probes Based on an Open Conformation of a Cytochrome P450 1B1 Complex for Molecular Imaging of Colorectal Tumors [J]. Journal of Medicinal Chemistry, 2023, 66(23): 16032-50. https://doi.org/10.1021/acs.jmedchem.3c01474.

【English Synonyms】

3H-Indolium,2-[(1E,3Z,5E)-3-[4-[21-[[2-(aminocarbonyl)-5-(4,5,6,7-tetrahydro-3,6,6-trimethyl-4-oxo-1H-indazol-1-yl)phenyl]amino]-6,9,12,15,18-pentaoxa-Chemicalbook2-azaheneicos-1-yl]phenyl]-5-[1,3-dihydro-3,3-dimethyl-1-(4-sulfobutyl)-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-3,3-dimethyl-1-(4-sulfobutyl)-,innersalt.

【Description】

HS-131 is a near-infrared Hsp90 dye inhibitor that is sensitive and specific to all molecular subtypes of mouse and human breast cancer, and has a high uptake rate in invasive and highly metastatic clones.

【References】

OSADA T, KANEKO K, GWIN W R, et al. In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior [J]. Clin Cancer Res, 2017, 23(24): 7531-42. DOI: 10.1158/1078-0432.CCR-17-1453.

【English Synonyms】

9-((1-(6-(4-(5,5-difluoro-1,3,7,9-tetramethyl-9a,10-dihydro-5H-5l4,6l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-10-yl)phenoxy)hexyl)-1H-1,2,3-triazol-4-yl)methoxy)-10-methoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium.

【Description】

BBR-BODIPY is a novel berberine derivative with excellent cell penetration ability, which is mainly concentrated in mitochondria. BBR-BODIPY can induce apoptosis and change the expression of apoptosis-related proteins.

【References】

JIN M, JI X, STOIKA R, et al. Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study [J]. Bioorganic Chemistry, 2020, 101: 104021. https://doi.org/10.1016/j.bioorg.2020.104021.

【English Synonyms】

mono(4-((1E,3Z)-3-(3-methylbenzo[d]thiazol-2(3H)-ylidene)prop-1-en-1-yl)-1-(3-(trimethylammonio)propyl)quinolin-1-ium) monoiodide.

【Description】

TO-PRO-3 iodide is a highly efficient blue fluorescent dye that can be used as a cell tracer to stain the cytoplasm.

【References】

patent

【English Synonyms】

4-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dien-1-yl)-1-(4-((diphenylphosphoryl)oxy)benzyl)quinolin-1-ium bromide.

【Description】

MQA-P is a multifunctional near-infrared fluorescent probe based on excited state intramolecular charge transfer, which can simultaneously detect ONOO −, viscosity and polarity in mitochondria. MQA-P is used for ferroptosis or cancer diagnosis in vitro an

【References】

FAN L, YANG Q, ZAN Q, et al. Multifunctional Fluorescent Probe for Simultaneous Detection of ONOO–, Viscosity, and Polarity and Its Application in Ferroptosis and Cancer Models [J]. Analytical Chemistry, 2023, 95(13): 5780-7. https://doi.org/10.1021/acs.analchem.3c00142.

【English Synonyms】

(E)-1-ethyl-2-(2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-3H-indol-1-ium iodide.

【Description】

PA-HD is a new type of dye scaffold optimized for the development of PA probes. It is characterized by a 4.8-fold increase in sensitivity and a red shift of λabs from 690 nm to 745 nm, thereby achieving ratio imaging.

【References】

GARDNER S H, BRADY C J, KEETON C, et al. A General Approach to Convert Hemicyanine Dyes into Highly Optimized Photoacoustic Scaffolds for Analyte Sensing [J]. Angewandte Chemie International Edition, 2021, 60(34): 18860-6. https://doi.org/10.1002/anie.202105905.

【English Synonyms】

2-(7-(dimethylamino)-3-(dimethyliminio)-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)-4-((4-(4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)phenoxy)butyl)carbamoyl)benzoate.

【Description】

SiR-Hoechst is a far-red fluorescent DNA probe, which is widely used for delayed imaging of living cells. SiR-Hoechst has minimal toxicity at concentrations up to 10-25 wM, and induces DNA damage response and G2 stagnation at concentrations below 1 pM.

【References】

SEN O, SAURIN A T, HIGGINS J M G. The live cell DNA stain SiR-Hoechst induces DNA damage responses and impairs cell cycle progression [J]. Sci Rep, 2018, 8(1): 7898. DOI: 10.1038/s41598-018-26307-6.

【English Synonyms】

(E)-4-(2-(3-(dicyanomethylene)-5,5-dimethylcyclohex-1-en-1-yl)vinyl)phenyl trifluoromethanesulfonate.

【Description】

NIR-FP is a near-infrared fluorescent probe with high sensitivity and selectivity for superoxide anion O2-. O2-is the main precursor of ROS, and the ferroptosis-mediated epilepsy model can be dynamically tracked by detecting O2-.

【References】

YANG W, LIU R, YIN X, et al. Novel Near-Infrared Fluorescence Probe for Bioimaging and Evaluating Superoxide Anion Fluctuations in Ferroptosis-Mediated Epilepsy [J]. Analytical Chemistry, 2023, 95(33): 12240-6. https://doi.org/10.1021/acs.analchem.3c00852.

【English Synonyms】

3-ethyl-2-((E)-2-((E)-3-((Z)-2-(3-ethylbenzo[d]thiazol-2(3H)-ylidene)ethylidene)-6-oxocyclohexa-1,4-dien-1-yl)vinyl)benzo[d]thiazol-3-ium bromide.

【Description】

BTCy is a near-infrared ( NIR ) fluorescent probe with polarity response and plasma membrane targeting properties. BTCy can be used for in vivo imaging of tumor tissues ( λex = 561 nm, λem = 600-700 nm ).

【References】

Liu J, et al. Monitoring Cell Plasma Membrane Polarity by a NIR Fluorescence Probe with Unexpected Cell Plasma Membrane-Targeting Ability. ACS Omega. 2022 Dec 9;7(50):46891-46899. https://doi.org/10.1021/acsomega.2c05997.

【English Synonyms】

(E)-9-(2-carboxyphenyl)-6-(diethylamino)-4-((10-ethyl-2-methoxy-10H-phenothiazin-3-yl)methylene)-1,2,3,4-tetrahydroxanthylium hypochlorite.

【Description】

Mito-Rh-S is a near-infrared fluorescent probe that can detect fluctuations in mitochondrial HCIO levels during ferroptosis in hepatocellular carcinoma ( HCC ).

【References】

ZHAO B, XU X, WEN X, et al. Ratiometric Near-Infrared Fluorescent Probe Monitors Ferroptosis in HCC Cells by Imaging HClO in Mitochondria [J]. Analytical Chemistry, 2024, 96(15): 5992-6000. https://doi.org/10.1021/acs.analchem.4c00328.

【English Synonyms】

2-((E)-4-((4-((E)-2-(benzo[d]thiazol-2-yl)vinyl)phenyl)(phenyl)amino)styryl)-3-methylbenzo[d]thiazol-3-ium iodide.

【Description】

BETA-1 is the first intramolecular charge transfer aggregation-induced emission integrated molecule, which emits cyan fluorescence in lipid droplets ( LD ) and red fluorescence in mitochondria. BETA-1 can be used for simultaneous dual-color imaging of lip

【References】

ZENG S-T, SHAO W, YU Z-Y, et al. Construction of a TICT-AIE-Integrated Unimolecular Platform for Imaging Lipid Droplet–Mitochondrion Interactions in Live Cells and In Vivo [J]. ACS Sensors, 2023, 8(1): 40-50. https://doi.org/10.1021/acssensors.2c01361.

【English Synonyms】

1-ethyl-2-((1E,3Z)-3-(1-ethylnaphtho[1,2-d]thiazol-2(1H)-ylidene)-2-methylprop-1-en-1-yl)naphtho[1,2-d]thiazol-1-ium bromide.

【Description】

Stain-All is a cationic carbocyanine dye that can dye sialic acid glycoproteins into blue, Ca2 + binding proteins into dark blue to purple, and proteins and lipids into red and yellow orange, respectively. It is a portable probe for studying the structura

【References】

Campbell KP, et al. Staining of the Ca2+-binding proteins, calsequestrin, calmodulin, troponin C, and S-100, with the cationic carbocyanine dye “Stains-all” [J]. (0021-9258 (Print)).

【English Synonyms】

(E)-2-(2-(6-((dimethylcarbamoyl)oxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-1-ethylquinolin-1-ium iodide.

【Description】

QXMC had excellent BBB penetration ability, reduced AChE activity in the brain of acute epileptic mice for the first time, and restored AChE levels in the brain of epileptic mice treated with curcumin.

【References】

FAN L, WANG R, ZAN Q, et al. A Near-Infrared Fluorescent Probe for Visualization of Acetylcholinesterase Flux in the Acute Epileptic Mice Brain [J]. Chemical & Biomedical Imaging, 2024. https://doi.org/10.1021/cbmi.4c00058.

【English Synonyms】

(E)-2-(benzo[d]thiazol-2-yl)-3-(4-(diethylamino)-2-(2,4-dinitrophenoxy)phenyl)acrylonitrile.

【Description】

BTDA-RSS is a LD-targeted biothiol-sensitive fluorescent probe that has been successfully used to distinguish cancer cells / tissues from normal cells / tissues with good contrast, providing great potential for clinical diagnosis of human cancer.

【References】

YU X, HUANG Y, ZHANG N, et al. A lipid droplet-targeting fluorescent probe for specific H2S imaging in biosamples and development of smartphone platform [J]. Analytica Chimica Acta, 2023, 1277: 341679. https://doi.org/10.1016/j.aca.2023.341679.

【English Synonyms】

(E)-2-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)-5-(diethylamino)phenyl 2,4-dinitrobenzenesulfonate.

【Description】

BTDA-RSS is a LD-targeted biothiol-sensitive fluorescent probe that has been successfully used to distinguish cancer cells / tissues from normal cells / tissues with good contrast, providing great potential for clinical diagnosis of human cancer.

【References】

ZHANG Y, ZHANG N, WANG S, et al. A lipid droplet-targetable and biothiol-sensitive fluorescent probe for the diagnosis of cancer cells/tissues [J]. Analyst, 2022, 147(8): 1695-701. https://doi.org/10.1039/D2AN00030J.

【English Synonyms】

(Z)-1-(4-acetoxybenzyl)-4-(4-(1-cyano-2-(6-(dimethylamino)-1-methoxynaphthalen-2-yl)vinyl)phenyl)pyridin-1-ium bromide

【Description】

NAP-Py-E is a near-infrared AIE probe with two-color emission for mitochondrial and lipid droplet imaging. NAP-Py-E first targeted mitochondria and emitted red fluorescence ; after partial hydrolysis by esterase in living cells, the hydrolysate NAP-Py acc

【References】

WANG S-H, ZHANG Y-W, WANG X-D, et al. An esterase-sensitive AIEgen probe targeting mitochondria and lipid droplets for assessing cell viability [J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 287: 122122. https://doi.org/10.1016/j.saa.2022.122122.

【English Synonyms】

(E)-1-(4-acetoxybenzyl)-4-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)pyridin-1-ium

【Description】

Mito-TTPE is a multifunctional aggregation-induced emission gene, which first emits near-infrared fluorescence in mitochondria, and then is partially hydrolyzed by esterase, resulting in the accumulation of lipophilic and blue-emitting LD-TTP in lipid dro

【References】

FAN L, ZAN Q, WANG X, et al. A Mitochondria-Specific Orange/Near-Infrared-Emissive Fluorescent Probe for Dual-Imaging of Viscosity and HO in Inflammation and Tumor Models [J]. Chinese Journal of Chemistry, 2021, 39(5): 1303-9. https://doi.org/10.1039/D1QM01270C.

【English Synonyms】

(E)-1-(4-boronobenzyl)-4-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)pyridin-1-ium.

【Description】

TTPB has good mitochondrial specificity and can detect the viscosity of the near-infrared channel and the H2O2 level of the orange channel in living cells. TTPB was successfully applied to simultaneous imaging of viscosity and H2O2 levels in inflammation

【References】

FAN L, ZAN Q, WANG X, et al. A Mitochondria-Specific Orange/Near-Infrared-Emissive Fluorescent Probe for Dual-Imaging of Viscosity and HO in Inflammation and Tumor Models [J]. Chinese Journal of Chemistry, 2021, 39(5): 1303-9. https://doi.org/10.1002/cjoc.202000725

【English Synonyms】

(Z)-1-(4-(chloromethyl)benzyl)-4-(4-(1-cyano-2-(4-(diethylamino)-2-methoxyphenyl)vinyl)phenyl)pyridin-1-ium.

【Description】

CS-Py-BC is a mitochondria-targeted NIR emission aggregation-induced emission ( AIE ) probe that selectively responds to viscosity, enabling real-time monitoring of viscosity changes during mitophagy.

【References】

WANG X, FAN L, WANG S, et al. Real-Time Monitoring Mitochondrial Viscosity during Mitophagy Using a Mitochondria-Immobilized Near-Infrared Aggregation-Induced Emission Probe [J].Analytical Chemistry 2021 93 (6), 3241-3249. DOI: 10.1021/acs.analchem.0c04826.

【English Synonyms】

(Z)-4-(4-(1-cyano-2-(4-(diethylamino)-2-methoxyphenyl)vinyl)phenyl)-1-methylpyridin-1-ium .

【Description】

CSP has the characteristics of aggregation-induced emission ( AIE ) and near-infrared ( NIR ) solid-state emission, which can be used to track the changes of mitochondrial membrane potential ( MMP ) in situ in real time. CSP specifically stains mitochondr

【References】

【English Synonyms】

4-(5,5-difluoro-7-(4-(2-((2-(2-(2-(4-(2-(((2-isopropylphenoxy)carbonyl)amino)ethyl)phenoxy)ethoxy)ethoxy)ethyl)amino)-2-oxoethoxy)phenyl)-1,9-diphenyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2',1'-f][1,3,5,2]triazaborinin-3-yl)-N,N-diethylaniline oxide.

【Description】

NOx-JS013 is a near-infrared fluorescent dye.

【References】

SONG J., ZHAI T., HAHM H. S., et al. Development of a Dual-Factor Activatable Covalent Targeted Photoacoustic Imaging Probe for Tumor Imaging [J]. Angew. Chem. Int. Ed., 2024, 63(40): e202410645.

【English Synonyms】

2-((1E,3E)-5-((E)-3,3-dimethyl-1-(6-oxo-6-((3-((2-oxo-2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)phenyl)ethyl)amino)propyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-1-(4-sulfobutyl)-3H-indol-1-ium-5-sulfonate.

【Description】

AF646 Pyr Te is a near-infrared fluorescent dye that can image specific proteins.

【References】

KOZMA E., KELE P. Bioorthogonal Reactions in Bioimaging [J]. Top. Curr. Chem., 2024, 382(1): 7.

【English Synonyms】

(1-ethyl-10,10-dimethyl-11-(4-((4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)amino)-4-oxobutyl)-3,4,8,9,10,11-hexahydro-2H-dipyrido[3,2-b:2',3'-i]phenoxazin-1-ium-7-yl)methanesulfonate.

【Description】

Me Tet-ATTO655 is a near-infrared fluorescent dye that can be used for cell imaging through click reactions.

【References】

DING B., XIAO Y., ZHOU H., et al. Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-Infrared Subwindow [J]. J. Med. Chem., 2019, 62(4): 2049-2059.

【English Synonyms】

2-((1E,3E)-5-((E)-1-(6-((3-azidopropyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-1-ethyl-3,3-dimethyl-3H-indol-1-ium-5-sulfonate

【Description】

CY5-N3 is a near-infrared fluorescent dye that can be used for cell imaging through click reactions.

【References】

LAM Y. Y., TAN A., NOWELL C. J., et al. Systematic Investigation of Metabolic Oligosaccharide Engineering Efficiency in Intestinal Cells Using a Dibenzocyclooctyne-Monosaccharide Conjugate [J]. ChemBioChem, 2023, 24(12): e202300144.

【English Synonyms】

1-(1-((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)-3,14-dioxo-2,7,10-trioxa-4,13-diazanonadecan-19-yl)-3,3-dimethyl-2-((E)-3-((E)-1,3,3-trimethylindolin-2-ylidene)prop-1-en-1-yl)-3H-indol-1-ium chloride.

【Description】

Cy3-PEG2-endo-BCN is a near-infrared fluorescent dye that can be used for cell imaging through click reactions.

【References】

ZHU L., XU Y., WEI X., et al. Coupling Aptamer-based Protein Tagging with Metabolic Glycan Labeling for In Situ Visualization and Biological Function Study of Exosomal Protein-Specific Glycosylation [J]. Angew. Chem. Int. Ed., 2021, 60(33): 18111-18115.

【English Synonyms】

N/A

【Description】

Cyanine5 DBCO is a near-infrared fluorescent dye that can be used for cell imaging through click reactions.

【References】

ZHU L., XU Y., WEI X., et al. Coupling Aptamer-based Protein Tagging with Metabolic Glycan Labeling for In Situ Visualization and Biological Function Study of Exosomal Protein-Specific Glycosylation [J]. Angew. Chem. Int. Ed., 2021, 60(33): 18111-18115.

【English Synonyms】

N/A

【Description】

Cy3B NHS ester is an active fluorescent agent that can be used to specifically label amino groups in antibodies, peptides, or oligonucleotides.

【References】

KUMAR A., BHARADWAJ A., CHOUDHURY P., et al. Tuning the excitation laser power in a stochastic optical reconstruction microscope for Alexa Fluor 647 dye in Vectashield mounting media [J]. Rev. Sci. Instrum., 2024, 95(8).

【English Synonyms】

2-((1E,3E)-5-((E)-1-(6-((2,5-dioxopyrrolidin-1-yl)oxy)-6-oxohexyl)-3,3-dimethylindolin-2-ylidene)penta-1,3-dien-1-yl)-1-ethyl-3,3-dimethyl-3H-indol-1-ium chloride

【Description】

NIR-641 N-Succinimidyl ester is a near-infrared fluorescent dye with amine reactivity.

【References】

【English Synonyms】

(1-(4-((2,5-dioxopyrrolidin-1-yl)oxy)-4-oxobutyl)-11-ethyl-2,2-dimethyl-1,2,8,9,10,11-hexahydrodipyrido[3,2-b:2',3'-i]phenoxazin-13-ium-4-yl)methanesulfonate

【Description】

ATTO 680 NHS ester is a fluorescent dye based on Rhodamine structure, with strong absorption ability, high photostability and thermal stability, and good water solubility. It is best excited in the wavelength range of 645-695 nm and can label proteins or

【References】

KIM H., CHOI H. S., KIM S.-K., et al. Antigen-responsive molecular sensor enables real-time tumor-specific imaging [J]. Theranostics, 2017, 7(4): 952-961.