【English Synonyms】

2-((1E,3E,5E)-7-((E)-1-(1-amino-142-oxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69,72,75,78,81,84,87,90,93,96,99,102,105,108,111,114,117,120,123,126,129,132,135,138-hexatetracontaoxa-141-azaheptatetracontahectan-147-yl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)hepta-1,3,5-trien-1-yl)-1-ethyl-3,3-dimethyl-3H-indol-1-ium-6-sulfonate

【Description】

CY7-PEG-NH2 is a functional fluorescent marker that combines Cy7 dye, polyethylene glycol ( PEG ) chain and amino ( NH2 ).

【References】

Mann AP, et al. Thioaptamer conjugated liposomes for tumor vasculature targeting. Oncotarget. 2011 Apr;2(4):298-304.

【English Synonyms】

4-((E)-2-((E)-2-chloro-3-(2-((E)-7-(dimethylamino)-2-phenyl-4H-chromen-4-ylidene)ethylidene)cyclohex-1-en-1-yl)vinyl)-7-(dimethylamino)-2-phenylchromenylium perchlorate

【Description】

FLAV7 is a water-soluble, ester-soluble, near-infrared II dye.

【References】

【English Synonyms】

5-chloro-2-((E)-2-((E)-3-((Z)-2-(5-chloro-3-ethylbenzo[d]thiazol-2(3H)-ylidene)ethylidene)-2-(diphenylamino)cyclopent-1-en-1-yl)vinyl)-3-ethylbenzo[d]thiazol-3-ium perchlorate

【Description】

IR-140 is suitable for use as a laser dye

【References】

Chen W, Cheng CA, Cosco ED, Ramakrishnan S, Lingg JGP, Bruns OT, Zink JI, Sletten EM. Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles. J Am Chem Soc. 2019 Aug 14;141(32):12475-12480. doi: 10.1021/jacs.9b05195. Epub 2019 Aug 2. PMID: 31353894; PMCID: PMC6746239.

【English Synonyms】

11-(3-carboxypropyl)-1-ethyl-2,2,4,10,10-pentamethyl-8-(sulfomethyl)-10,11-dihydro-2H-dipyrido[3,2-b:2',3'-i]phenoxazin-1-ium chloride

【Description】

ATTO 700 is a new type of fluorescent dye with high fluorescence yield, which can be used for most labeling applications, maximum excitation/emission wavelength: 700/716 nm.

【References】

S. Nazeer, A. Saraswathy, N. Nimi, H. Santhakumar, P. Radhakrishnapillai Suma, S. Shenoy, R. Jayasree, Near infrared-emitting multimodal nanosystem for in vitro magnetic hyperthermia of hepatocellular carcinoma and dual imaging of in vivo liver fibrosis, Scientific reports 13, 12947 (2023).

【English Synonyms】

2-((E)-2-((E)-2-chloro-3-(2-((E)-1,3,3-trimethylindolin-2-ylidene)ethylidene)cyclopent-1-en-1-yl)vinyl)-1,3,3-trimethyl-3H-indol-1-ium chloride

【Description】

IR-797 chloride is a near-infrared (NIR) dye. IR 797 has absorption maxima near 700 nm. IR-797 shows some aggregation-induced-emission (AIE) properties. IR-797 shows shows cytotoxic.

【References】

Fan Cao, et al. Wavelength-Dependent Tip-Enhanced Laser Ablation of Organic Dyes. The Journal of Physical Chemistry C. 2020, 124, 3, 1918–1922.

【English Synonyms】

4-(2-((E)-2-((E)-2-chloro-3-((E)-2-(1-(4-sulfobutyl)benzo[cd]indol-2(1H)-ylidene)ethylidene)cyclopent-1-en-1-yl)vinyl)benzo[cd]indol-1-ium-1-yl)butane-1-sulfonate

【Description】

FD dye 7 (compound 7) is an intermediate of heptamethacyanine dye fluorescent dye and can be used to synthesize dyes FD-1 and FD-2.

【References】

Near IR second window excitation/emission fluorescent dye and preparation method thereof. China, CN110041723 A 2019-07-23.

【English Synonyms】

2-((E)-2-((E)-2-chloro-3-((E)-2-(1,1,3-trimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)ethylidene)cyclohex-1-en-1-yl)vinyl)-1,1,3-trimethyl-1H-benzo[e]indol-3-ium perchlorate

【Description】

IR 813 perchlorate is a near-infrared (NIR) fluorescent dye (Ex=815 nm, Em=840 nm) and can be used for visualizing regional lymph nodes in mice.

【References】

Marion Hell, et al. Surface chemistry architecture of silica nanoparticles determine the efficiency of in vivo fluorescence lymph node mapping. ACS Nano. 2013 Oct 22;7(10):8645-57.

【English Synonyms】

Sodium 4-((E)-2-((E)-2-(2-chloro-3-((E)-2-(3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-2-yl)vinyl)cyclopent-2-en-1-ylidene)ethylidene)-3,3-dimethylindolin-1-yl)butane-1-sulfonate

【Description】

IR-806 is a near-infrared cyanine liquid crystal dye. IR-806 can be used as a molecular antenna to synthesized nanoprobes (NPs). IR-806 can be used for in vivo imaging studies.

【References】

Wei Y, et al. Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy. Int J Nanomedicine. 2020 Mar 2;15:1409-1420.

【English Synonyms】

4-((E)-2-((2E,4E,6E)-7-(3-(6-((6-aminohexyl)amino)-6-oxohexyl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-2-yl)hepta-2,4,6-trien-1-ylidene)-1,1-dimethyl-1,2-dihydro-3H-benzo[e]indol-3-yl)butane-1-sulfonate

【Description】

ICG amine, as a near-infrared fluorescent probe, binds to amino acid residues without condensing agents. ICG is a tricarbocyanine dye.

【References】

Badaracco AG, et al. Indocyanine green modified silica shells for colon tumor marking. Appl Surf Sci. 2020;499:143885.

【English Synonyms】

Sodium 4-((E)-2-((E)-2-(2-chloro-3-((E)-2-(1-(4-sulfonatobutyl)benzo[cd]indol-1-ium-2-yl)vinyl)cyclohex-2-en-1-ylidene)ethylidene)benzo[cd]indol-1(2H)-yl)butane-1-sulfonate

【Description】

FD-1080 free acid is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 free acid can be used for in vivo imaging.

【References】

Benhao Li, et al. An Efficient 1064 nm NIR-II Excitation Fluorescent Molecular Dye for Deep-Tissue High-Resolution Dynamic Bioimaging. Angew Chem Int Ed Engl. 2018 Jun 18;57(25):7483-7487.

【English Synonyms】

2-((1E,3E)-5-((E)-3,3-dimethyl-1-octadecylindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-1-octadecyl-3H-indol-1-ium iodide

【Description】

DiD dye is a lipophilic fluorescent dye, which is mainly used to stain cell membranes and other fat-soluble biological structures.

【References】

Meng Li, et al. In Vivo Tracking of Human Adipose-derived Mesenchymal Stem Cells in a Rat Knee Osteoarthritis Model with Fluorescent Lipophilic Membrane Dye. J Vis Exp. 2017; (128): 56273.

【English Synonyms】

3-(2-carboxyethyl)-2-((1E,3E,5E,7E)-7-(3-(2-carboxyethyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)hepta-1,3,5-trien-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium chloride

【Description】

Cypate is an anthocyanin dye that is a near-infrared ( NIR ) fluorescent probe for in vivo tumor imaging.

【References】

Wang L, et al. Cypate-conjugated porous upconversion nanocomposites for programmed delivery of heat shock protein 70 small interfering RNA for gene silencing and photothermal ablation[J]. Advanced Functional Materials, 2016, 26(20): 3480-3489.

【English Synonyms】

1-Butyl-2-[2-[3-[2-(1-butyl-6-chlorobenz[cd]indol-2(1H)-ylidene)ethylidene]-2-chloro-1-cyclohexen-1-yl]ethenyl]-6-chlorobenz[cd]indolium tetrafluoroborate

【Description】

IR-1048 (S01448) is a dye and also is a photothermal agent. IR-1048 can be used for the research of tumor diagnosis.

【References】

Xiaoxu Kang, et al. Dual-Cascade Responsive Nanoparticles Enhance Pancreatic Cancer Therapy by Eliminating Tumor-Resident Intracellular Bacteria. Adv Mater. 2022 Dec;34(49):e2206765.

【English Synonyms】

Sodium 2-((E)-2-((E)-2-chloro-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate

【Description】

S0456 is a near-infrared ( NIR ) fluorescent dye that can be used to synthesize Pafolacianine ( HY-139579 ).

【References】

Mahalingam SM, et al. Evaluation of Novel Tumor-Targeted Near-Infrared Probe for Fluorescence-Guided Surgery of Cancer. J Med Chem. 2018 Nov 8;61(21):9637-9646.

【English Synonyms】

1-(5-carboxypentyl)-2-((E)-2-((E)-3-(2-((E)-1-(5-carboxypentyl)-3,3-dimethylindolin-2-ylidene)ethylidene)-2-chlorocyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-3H-indol-1-ium bromide

【Description】

IR808 ( MHI-148 ) is a near-infrared heptamethine cyanine dye with tumor targeting.

【References】

Athira Raveendran, et al. Heptamethine Cyanine Dye MHI-148-Mediated Drug Delivery System to Enhance the Anticancer Efficiency of Paclitaxel. Int J Nanomedicine. 2021 Oct 21;16:7169-7180.

【English Synonyms】

1-(5-carboxypentyl)-2-((E)-2-((E)-3-((E)-2-(1-(5-carboxypentyl)benzo[cd]indol-2(1H)-ylidene)ethylidene)-2-chlorocyclohex-1-en-1-yl)vinyl)benzo[cd]indol-1-ium iodide

【Description】

CO-1080 is a near-infrared region II (NIR-II) fluorescent dye primarily used in biological imaging and medical research..

【References】

Site-specific albumin tagging with NIR-II fluorogenic dye for high-performance and super-stable bioimaging Ningning Zhu+, Jiajun Xu+, Qi Su, Tianyang Han, Ding Zhou,* Yuewei Zhang,* Shoujun Zhu,* Theranostics, 2024, 14, 1860.

【English Synonyms】

3-(4-carboxybenzyl)-2-((E)-2-((E)-3-((E)-2-(3-(4-carboxybenzyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)ethylidene)-2-chlorocyclohex-1-en-1-yl)vinyl)-1,1-dimethyl-1H-benzo[e]indol-3-ium bromide

【Description】

IR-825 is a near-infrared dye ( NIR ). IR-825 was encapsulated into nanoparticles. The IR-825 nanoparticles exhibit pH-dependent fluorescence emission and excellent near-infrared ( NIR ) radiation to target cells in vitro to provide cytotoxicity.

【References】

Wang X, et al. Synergistic chemo-photothermal cancer therapy of pH-responsive polymeric nanoparticles loaded IR825 and DTX with charge-reversal property. Colloids Surf B Biointerfaces. 2022;209(Pt 2):112164.

【English Synonyms】

3-(5-carboxypentyl)-2-((1E,3E,5E,7E)-7-(3-(5-carboxypentyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)hepta-1,3,5-trien-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium bromide

【Description】

ICG is a negatively charged polymethylcyanine dye with good water solubility.

【References】

6-Aminocaproic acid as a linker to improve near-infrared fluorescence imaging and photothermal cancer therapy of PEGylated indocyanine green.

【English Synonyms】

1,1,3-trimethyl-2-((1E,3E,5E)-5-(1,1,3-trimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)penta-1,3-dien-1-yl)-1H-benzo[e]indol-3-ium iodide

【Description】

IR-676 is a cyanine dye with an absorption wavelength of nearly 680 nm.

【References】

Hydrophobic cyanine dye-doped micelles for optical in vivo imaging of plasma leakage and vascular disruption.Journal of Biomedical Optics ( IF 3.0 ) Pub Date : 2015-01-30 , DOI: 10.1117/1.jbo.20.1.016022 Bálint Botz 1 , Kata Bölcskei 1 , Ágnes Kemény 1 , Zoltán Sándor 2 , Valéria Tékus 1 , György Sétáló 3 , Janka Csepregi 4 , Attila Mócsai 4 , Erika Pintér 1 , László Kollár 5 , Zsuzsanna Helyes 1.

【English Synonyms】

2-((E)-2-((E)-2-chloro-3-(2-((E)-1,3,3-trimethylindolin-2-ylidene)ethylidene)cyclopent-1-en-1-yl)vinyl)-1,3,3-trimethyl-3H-indol-1-ium iodide

【Description】

IR-797 chloride is a near-infrared ( NIR ) dye. The maximum absorption wavelength of IR 797 is close to 700 nm. IR-797 shows some aggregation-induced emission ( AIE ) properties.

【References】

Fan Cao, et al. Wavelength-Dependent Tip-Enhanced Laser Ablation of Organic Dyes. The Journal of Physical Chemistry C. 2020, 124, 3, 1918–1922.

【English Synonyms】

2-((E)-2-((E)-2-chloro-3-(2-((E)-1,3,3-trimethylindolin-2-ylidene)ethylidene)cyclohex-1-en-1-yl)vinyl)-1,3,3-trimethyl-3H-indol-1-ium iodide

【Description】

IR-775 chloride is a solvent-soluble, laser and near-infrared dye.

【References】

IR-775 - Hyptis loaded bioactive nanoparticles for enhanced phyto-photothermal therapy of breast cancer cells Photodiagnosis and Photodynamic Therapy ( IF 3.1 ) Pub Date : 2023-11-04 , DOI: 10.1016/j.pdpdt.2023.103872Monika Pebam 1 , Mohammad Sadik Ali 1 , Sajmina Khatun 1 , Aravind Kumar Rengan 1.

【English Synonyms】

Sodium 4-((E)-2-((E)-2-(2-chloro-3-((E)-2-(3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-2-yl)vinyl)cyclohex-2-en-1-ylidene)ethylidene)-3,3-dimethylindolin-1-yl)butane-1-sulfonate

【Description】

IR-783 (ADS 780WS) is a near-infrared (NIR) heptamethine cyanine fluorescent probe. IR-783 significantly inhibits tumour growth and induces apoptosis in MDA-MB-231 xenograft model. IR-783 can be used to study breast cancer.

【References】

Tang Q, et al. Dynamin-related protein 1-mediated mitochondrial fission contributes to IR-783-induced apoptosis in human breast cancer cells. J Cell Mol Med. 2018 Sep;22(9):4474-4485.

【English Synonyms】

2-((E)-2-((E)-2-chloro-3-(2-((E)-3,3-dimethyl-1-propylindolin-2-ylidene)ethylidene)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-propyl-3H-indol-1-ium iodide

【Description】

IR-780 is a typical near-infrared heptamethyl cyanine fluorescent dye with high molar extinction coefficient. IR-780 can be used for tumor PTT / PDT and imaging, and is expected to be used in biomedical applications and drug delivery.

【References】

Cátia G Alves., Rita Lima-Sousa., Duarte de Melo-Diogo., et al. IR780 based nanomaterials for cancer imaging and photothermal, photodynamic and combinatorial therapies[J]. Int J Pharm. 2018 542(1-2):164-175