【English Synonyms】

(E)-2-(2-(8-ethyl-5,5-difluoro-7,9-dimethyl-3-((4-nitrophenyl)thio)-10-phenyl-5H-5l4,6l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-2-yl)vinyl)-1,1-dimethyl-3-(3-sulfopropyl)-1H-benzo[e]indol-3-ium.

【Description】

WH-1 is a near-infrared fluorescent probe with a D-π-A molecular skeleton. The probe is activated by H2S, and the emission maximum is between 925 and 1205 nm, which is attributed to the cooperation of lengthening the π-conjugated system and enhancing the

【References】

DOU K, FENG W, FAN C, et al. Flexible Designing Strategy to Construct Activatable NIR-II Fluorescent Probes with Emission Maxima beyond 1200 nm [J]. Anal Chem, 2021, 93(8): 4006-14. DOI: 10.1021/acs.analchem.0c04990.

【English Synonyms】

9-((1-(6-(4-(5,5-difluoro-1,3,7,9-tetramethyl-9a,10-dihydro-5H-5l4,6l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-10-yl)phenoxy)hexyl)-1H-1,2,3-triazol-4-yl)methoxy)-10-methoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium.

【Description】

BBR-BODIPY is a novel berberine derivative with excellent cell penetration ability, which is mainly concentrated in mitochondria. BBR-BODIPY can induce apoptosis and change the expression of apoptosis-related proteins.

【References】

JIN M, JI X, STOIKA R, et al. Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study [J]. Bioorganic Chemistry, 2020, 101: 104021. https://doi.org/10.1016/j.bioorg.2020.104021.

【English Synonyms】

mono(4-((1E,3Z)-3-(3-methylbenzo[d]thiazol-2(3H)-ylidene)prop-1-en-1-yl)-1-(3-(trimethylammonio)propyl)quinolin-1-ium) monoiodide.

【Description】

TO-PRO-3 iodide is a highly efficient blue fluorescent dye that can be used as a cell tracer to stain the cytoplasm.

【References】

patent

【English Synonyms】

4-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dien-1-yl)-1-(4-((diphenylphosphoryl)oxy)benzyl)quinolin-1-ium bromide.

【Description】

MQA-P is a multifunctional near-infrared fluorescent probe based on excited state intramolecular charge transfer, which can simultaneously detect ONOO −, viscosity and polarity in mitochondria. MQA-P is used for ferroptosis or cancer diagnosis in vitro an

【References】

FAN L, YANG Q, ZAN Q, et al. Multifunctional Fluorescent Probe for Simultaneous Detection of ONOO–, Viscosity, and Polarity and Its Application in Ferroptosis and Cancer Models [J]. Analytical Chemistry, 2023, 95(13): 5780-7. https://doi.org/10.1021/acs.analchem.3c00142.

【English Synonyms】

(E)-2-(2-(7-chloro-6-hydroxy-2,3-dihydro-1H-thioxanthen-4-yl)vinyl)-1-ethyl-3,3-dimethyl-3H-indol-1-ium iodide.

【Description】

PA-HD is a new type of dye scaffold optimized for the development of photoacoustic imaging probes. It is characterized by a 4.8-fold increase in sensitivity and a red shift of λabs from 690 nm to 745 nm, thereby achieving ratio imaging.

【References】

GARDNER S H, BRADY C J, KEETON C, et al. A General Approach to Convert Hemicyanine Dyes into Highly Optimized Photoacoustic Scaffolds for Analyte Sensing [J]. Angewandte Chemie International Edition, 2021, 60(34): 18860-6. https://doi.org/10.1002/anie.202105905.

【English Synonyms】

(E)-1-ethyl-2-(2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3,3-dimethyl-3H-indol-1-ium iodide.

【Description】

PA-HD is a new type of dye scaffold optimized for the development of PA probes. It is characterized by a 4.8-fold increase in sensitivity and a red shift of λabs from 690 nm to 745 nm, thereby achieving ratio imaging.

【References】

GARDNER S H, BRADY C J, KEETON C, et al. A General Approach to Convert Hemicyanine Dyes into Highly Optimized Photoacoustic Scaffolds for Analyte Sensing [J]. Angewandte Chemie International Edition, 2021, 60(34): 18860-6. https://doi.org/10.1002/anie.202105905.

【English Synonyms】

(E)-7-chloro-9-(2-(methoxycarbonyl)phenyl)-6-((4-(((3R,4R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzyl)oxy)-4-(2-((E)-1,3,3-trimethylindolin-2-ylidene)ethylidene)-1,2,3,4-tetrahydroxanthylium.

【Description】

NIR-βgal-2 is a β-galactoside-activated near-infrared light probe with excellent optical resolution. NIR-βgal-2 can be used to visualize β-galactoside cakes in breast cancer.

【References】

WU Q, ZHOU Q-H, LI W, et al. Evolving an Ultra-Sensitive Near-Infrared β-Galactosidase Fluorescent Probe for Breast Cancer Imaging and Surgical Resection Navigation [J]. ACS Sensors, 2022, 7(12): 3829-37. 2022 Nov 16. https://doi.org/10.1021/acssensors.2c01752.

【English Synonyms】

(E)-3-ethyl-2-(2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl)-1,1-dimethyl-1H-benzo[e]indol-3-ium iodide.

【Description】

Near-IR fuorescent probe-1 is a multifunctional dye.

【References】

SULTANA M, ROWNOK M H, SABRIN M, et al. A review on experimental chemically modified activated carbon to enhance dye and heavy metals adsorption [J]. Cleaner Engineering and Technology, 2022, 6: 100382. https://doi.org/10.1016/j.clet.2021.100382.

【English Synonyms】

(Z)-2-(5-((10-(2-ethylhexyl)-10H-phenothiazin-3-yl)methylene)-4-oxo-3-(phenylamino)dihydrothiophen-2(3H)-ylidene)malononitrile.

【Description】

MIT-PZR has great potential in cell imaging due to its low cytotoxicity, good light stability and high mitochondrial targeting specificity. In addition, MIT-PZR has a considerable Stokes shift, which can penetrate tissues and provide stable red fluorescen

【References】

DONG Y, CHEN Z, HOU M, et al. Mitochondria-targeted aggregation-induced emission active near infrared fluorescent probe for real-time imaging [J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 224: 117456. https://doi.org/10.1016/j.saa.2019.117456.

【English Synonyms】

1-(4-((2-(triphenylphosphonio)ethyl)carbamoyl)benzyl)-4-((E)-3-((Z)-1-(4-((2-(triphenylphosphonio)ethyl)carbamoyl)benzyl)quinolin-4(1H)-ylidene)prop-1-en-1-yl)quinolin-1-ium bromide.

【Description】

Mito-CCY is a cyanine probe that targets mitochondria and has near-infrared absorption. Under light irradiation, Mito-CCy also showed high cytotoxicity to HeLa cells. This photo-induced cytotoxicity is due to endogenously produced reactive oxygen species

【References】

JUNG H S, LEE J-H, KIM K, et al. A Mitochondria-Targeted Cryptocyanine-Based Photothermogenic Photosensitizer [J]. Journal of the American Chemical Society, 2017, 139(29): 9972-8. https://doi.org/10.1021/jacs.7b04263.

【English Synonyms】

2-(7-(dimethylamino)-3-(dimethyliminio)-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)-4-((4-(4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)phenoxy)butyl)carbamoyl)benzoate.

【Description】

SiR-Hoechst is a far-red fluorescent DNA probe, which is widely used for delayed imaging of living cells. SiR-Hoechst has minimal toxicity at concentrations up to 10-25 wM, and induces DNA damage response and G2 stagnation at concentrations below 1 pM.

【References】

SEN O, SAURIN A T, HIGGINS J M G. The live cell DNA stain SiR-Hoechst induces DNA damage responses and impairs cell cycle progression [J]. Sci Rep, 2018, 8(1): 7898. DOI: 10.1038/s41598-018-26307-6.

【English Synonyms】

(E)-4-(2-(3-(dicyanomethylene)-5,5-dimethylcyclohex-1-en-1-yl)vinyl)phenyl trifluoromethanesulfonate.

【Description】

NIR-FP is a near-infrared fluorescent probe with high sensitivity and selectivity for superoxide anion O2-. O2-is the main precursor of ROS, and the ferroptosis-mediated epilepsy model can be dynamically tracked by detecting O2-.

【References】

YANG W, LIU R, YIN X, et al. Novel Near-Infrared Fluorescence Probe for Bioimaging and Evaluating Superoxide Anion Fluctuations in Ferroptosis-Mediated Epilepsy [J]. Analytical Chemistry, 2023, 95(33): 12240-6. https://doi.org/10.1021/acs.analchem.3c00852.

【English Synonyms】

3-ethyl-2-((E)-2-((E)-3-((Z)-2-(3-ethylbenzo[d]thiazol-2(3H)-ylidene)ethylidene)-6-oxocyclohexa-1,4-dien-1-yl)vinyl)benzo[d]thiazol-3-ium bromide.

【Description】

BTCy is a near-infrared ( NIR ) fluorescent probe with polarity response and plasma membrane targeting properties. BTCy can be used for in vivo imaging of tumor tissues ( λex = 561 nm, λem = 600-700 nm ).

【References】

Liu J, et al. Monitoring Cell Plasma Membrane Polarity by a NIR Fluorescence Probe with Unexpected Cell Plasma Membrane-Targeting Ability. ACS Omega. 2022 Dec 9;7(50):46891-46899. https://doi.org/10.1021/acsomega.2c05997.

【English Synonyms】

(E)-9-(2-carboxyphenyl)-6-(diethylamino)-4-((10-ethyl-2-methoxy-10H-phenothiazin-3-yl)methylene)-1,2,3,4-tetrahydroxanthylium hypochlorite.

【Description】

Mito-Rh-S is a near-infrared fluorescent probe that can detect fluctuations in mitochondrial HCIO levels during ferroptosis in hepatocellular carcinoma ( HCC ).

【References】

ZHAO B, XU X, WEN X, et al. Ratiometric Near-Infrared Fluorescent Probe Monitors Ferroptosis in HCC Cells by Imaging HClO in Mitochondria [J]. Analytical Chemistry, 2024, 96(15): 5992-6000. https://doi.org/10.1021/acs.analchem.4c00328.

【English Synonyms】

2-((E)-4-((4-((E)-2-(benzo[d]thiazol-2-yl)vinyl)phenyl)(phenyl)amino)styryl)-3-methylbenzo[d]thiazol-3-ium iodide.

【Description】

BETA-1 is the first intramolecular charge transfer aggregation-induced emission integrated molecule, which emits cyan fluorescence in lipid droplets ( LD ) and red fluorescence in mitochondria. BETA-1 can be used for simultaneous dual-color imaging of lip

【References】

ZENG S-T, SHAO W, YU Z-Y, et al. Construction of a TICT-AIE-Integrated Unimolecular Platform for Imaging Lipid Droplet–Mitochondrion Interactions in Live Cells and In Vivo [J]. ACS Sensors, 2023, 8(1): 40-50. https://doi.org/10.1021/acssensors.2c01361.

【English Synonyms】

1-ethyl-2-((1E,3Z)-3-(1-ethylnaphtho[1,2-d]thiazol-2(1H)-ylidene)-2-methylprop-1-en-1-yl)naphtho[1,2-d]thiazol-1-ium bromide.

【Description】

Stain-All is a cationic carbocyanine dye that can dye sialic acid glycoproteins into blue, Ca2 + binding proteins into dark blue to purple, and proteins and lipids into red and yellow orange, respectively. It is a portable probe for studying the structura

【References】

Campbell KP, et al. Staining of the Ca2+-binding proteins, calsequestrin, calmodulin, troponin C, and S-100, with the cationic carbocyanine dye “Stains-all” [J]. (0021-9258 (Print)).

【English Synonyms】

(E)-2-(2-(6-((dimethylcarbamoyl)oxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-1-ethylquinolin-1-ium iodide.

【Description】

QXMC had excellent BBB penetration ability, reduced AChE activity in the brain of acute epileptic mice for the first time, and restored AChE levels in the brain of epileptic mice treated with curcumin.

【References】

FAN L, WANG R, ZAN Q, et al. A Near-Infrared Fluorescent Probe for Visualization of Acetylcholinesterase Flux in the Acute Epileptic Mice Brain [J]. Chemical & Biomedical Imaging, 2024. https://doi.org/10.1021/cbmi.4c00058.

【English Synonyms】

(E)-2-(benzo[d]thiazol-2-yl)-3-(4-(diethylamino)-2-(2,4-dinitrophenoxy)phenyl)acrylonitrile.

【Description】

BTDA-RSS is a LD-targeted biothiol-sensitive fluorescent probe that has been successfully used to distinguish cancer cells / tissues from normal cells / tissues with good contrast, providing great potential for clinical diagnosis of human cancer.

【References】

YU X, HUANG Y, ZHANG N, et al. A lipid droplet-targeting fluorescent probe for specific H2S imaging in biosamples and development of smartphone platform [J]. Analytica Chimica Acta, 2023, 1277: 341679. https://doi.org/10.1016/j.aca.2023.341679.

【English Synonyms】

(E)-2-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)-5-(diethylamino)phenyl 2,4-dinitrobenzenesulfonate.

【Description】

BTDA-RSS is a LD-targeted biothiol-sensitive fluorescent probe that has been successfully used to distinguish cancer cells / tissues from normal cells / tissues with good contrast, providing great potential for clinical diagnosis of human cancer.

【References】

ZHANG Y, ZHANG N, WANG S, et al. A lipid droplet-targetable and biothiol-sensitive fluorescent probe for the diagnosis of cancer cells/tissues [J]. Analyst, 2022, 147(8): 1695-701. https://doi.org/10.1039/D2AN00030J.

【English Synonyms】

(Z)-1-(4-acetoxybenzyl)-4-(4-(1-cyano-2-(6-(dimethylamino)-1-methoxynaphthalen-2-yl)vinyl)phenyl)pyridin-1-ium bromide

【Description】

NAP-Py-E is a near-infrared AIE probe with two-color emission for mitochondrial and lipid droplet imaging. NAP-Py-E first targeted mitochondria and emitted red fluorescence ; after partial hydrolysis by esterase in living cells, the hydrolysate NAP-Py acc

【References】

WANG S-H, ZHANG Y-W, WANG X-D, et al. An esterase-sensitive AIEgen probe targeting mitochondria and lipid droplets for assessing cell viability [J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 287: 122122. https://doi.org/10.1016/j.saa.2022.122122.

【English Synonyms】

(E)-4-(2-(6-((4-hydroxyphenyl)(phenyl)amino)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-1-methylpyridin-1-ium iodide.

【Description】

POTA-OH can monitor fatty liver and inflammation, and has the potential of photodynamic therapy in vitro and in evaluating therapeutic effects. It has been successfully applied to the anti-tumor treatment of high-efficiency photodynamic therapy ( PDT ) in

【References】

FAN L, ZAN Q, WANG X, et al. A mitochondria-targeted and viscosity-sensitive near-infrared fluorescent probe for visualization of fatty liver, inflammation and photodynamic cancer therapy [J]. Chemical Engineering Journal, 2022, 449: 137762. https://doi.org/10.1016/j.cej.2022.137762.

【English Synonyms】

(E)-1-(4-acetoxybenzyl)-4-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)pyridin-1-ium

【Description】

Mito-TTPE is a multifunctional aggregation-induced emission gene, which first emits near-infrared fluorescence in mitochondria, and then is partially hydrolyzed by esterase, resulting in the accumulation of lipophilic and blue-emitting LD-TTP in lipid dro

【References】

FAN L, ZAN Q, WANG X, et al. A Mitochondria-Specific Orange/Near-Infrared-Emissive Fluorescent Probe for Dual-Imaging of Viscosity and HO in Inflammation and Tumor Models [J]. Chinese Journal of Chemistry, 2021, 39(5): 1303-9. https://doi.org/10.1039/D1QM01270C.

【English Synonyms】

(E)-1-(4-boronobenzyl)-4-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)pyridin-1-ium.

【Description】

TTPB has good mitochondrial specificity and can detect the viscosity of the near-infrared channel and the H2O2 level of the orange channel in living cells. TTPB was successfully applied to simultaneous imaging of viscosity and H2O2 levels in inflammation

【References】

FAN L, ZAN Q, WANG X, et al. A Mitochondria-Specific Orange/Near-Infrared-Emissive Fluorescent Probe for Dual-Imaging of Viscosity and HO in Inflammation and Tumor Models [J]. Chinese Journal of Chemistry, 2021, 39(5): 1303-9. https://doi.org/10.1002/cjoc.202000725

【English Synonyms】

(Z)-1-(4-(chloromethyl)benzyl)-4-(4-(1-cyano-2-(4-(diethylamino)-2-methoxyphenyl)vinyl)phenyl)pyridin-1-ium.

【Description】

CS-Py-BC is a mitochondria-targeted NIR emission aggregation-induced emission ( AIE ) probe that selectively responds to viscosity, enabling real-time monitoring of viscosity changes during mitophagy.

【References】

WANG X, FAN L, WANG S, et al. Real-Time Monitoring Mitochondrial Viscosity during Mitophagy Using a Mitochondria-Immobilized Near-Infrared Aggregation-Induced Emission Probe [J].Analytical Chemistry 2021 93 (6), 3241-3249. DOI: 10.1021/acs.analchem.0c04826.

【English Synonyms】

(Z)-4-(4-(1-cyano-2-(4-(diethylamino)-2-methoxyphenyl)vinyl)phenyl)-1-methylpyridin-1-ium .

【Description】

CSP has the characteristics of aggregation-induced emission ( AIE ) and near-infrared ( NIR ) solid-state emission, which can be used to track the changes of mitochondrial membrane potential ( MMP ) in situ in real time. CSP specifically stains mitochondr

【References】