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Common Name：ER-ZS
Emission Wavelength：600-700 nm
Fluorophore Types：Cyanine Dyes
Other Types：
CAS No.：N/A
Molecular Weight：976.5069
Formula：C39H36BrI2N3O4S
Storage：Sealed, in dark
Characteristics：N/A
(E)-2-(4-hydroxy-3,5-diiodostyryl)-1,1-dimethyl-3-(4-((2-((4-methylphenyl)sulfonamido)ethyl)carbamoyl)benzyl)-1H-benzo[e]indol-3-ium bromide.
ER-ZS can diagnose nonalcoholic fatty liver disease ( NAFLD ) by liver imaging based on high ER stress. ER-ZS is a type I photosensitizer that can produce O2 under light conditions. Photodynamic therapy causes severe oxidative damage to the endoplasmic re
ZENG S, WANG Y, CHEN C, et al. An ER-targeted, Viscosity-sensitive Hemicyanine Dye for the Diagnosis of Nonalcoholic Fatty Liver and Photodynamic Cancer Therapy by Activating Pyroptosis Pathway [J]. Angew Chem Int Ed Engl, 2024, 63(9): e202316487. https://doi.org/10.1002/anie.202316487.
DT62925019
DT62925019-5mg
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Common Name：YQ-04-03
Emission Wavelength：700-800 nm
Fluorophore Types：Cyanine Dyes
Other Types：
CAS No.：N/A
Molecular Weight：979.2470
Formula：C45H62N4O12S4
Storage：Sealed, in dark
Characteristics：Green flocculent solid
2-((E)-2-((E)-2-((3-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-3-oxopropyl)thio)-3-(2-((E)-3,3-dimethyl-1-(3-sulfopropyl)indolin-2-ylidene)ethylidene)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(3-sulfopropyl)-3H-indol-1-ium-5-sulfonate.
The retention time of YQ-04-03 in tumor was significantly longer than that in other non-specific uptake sites, and its tumor-to-normal tissue ratio ( TNR ) was better than that of ICG.
LIN Q, LI C, WANG Y, et al. Discovery of Near-Infrared Heptamethine Cyanine Probes for Imaging-Guided Surgery in Solid Tumors [J]. Journal of Medicinal Chemistry, 2024, 67(7): 5800-12. https://doi.org/10.1021/acs.jmedchem.4c00010.
DT62925018
DT62925018-5mg
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89100
80190
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Common Name：NCES
Emission Wavelength：600-700 nm
Fluorophore Types：Xanthene Derivatives
Other Types：
CAS No.：N/A
Molecular Weight：620.0580
Formula：C35H26ClN3O6
Storage：Sealed, in dark
Characteristics：Blue solid
methyl 2-(6-acetoxy-7-chloro-4-((E)-2-((Z)-4-cyano-5-(cyano(isocyano)methylene)-2,2-dimethyl-2,5-dihydrofuran-3-yl)vinyl)-2,3-dihydro-1H-xanthen-1-yl)benzoate.
NCES is used to guide liver cancer surgery through high-contrast in vivo imaging and to detect clinical serum samples from patients with liver cancer. NCES has great potential in drug development, medical diagnostic imaging applications, and early detecti
JIANG R, XIA Y, LIU Q, et al. Carboxylesterase-activated near-infrared fluorescence probe for highly sensitive imaging of liver tumors [J]. Journal of Materials Chemistry B, 2024, 12(6): 1530-7. https://doi.org/10.1039/D3TB02759G.
DT62925017
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Common Name：DCI-Br-3
Emission Wavelength：600-700 nm
Fluorophore Types：Other Types
Other Types：
CAS No.：N/A
Molecular Weight：474.3580
Formula：C25H20BrN3O2
Storage：Sealed, in dark
Characteristics：N/A
(E)-2-bromo-4-(2-(3-(dicyanomethylene)-5,5-dimethylcyclohex-1-en-1-yl)vinyl)phenyl isonicotinate.
DCI-Br-3 is a fast, highly sensitive and selective probe for the detection of epileptic brain thiols, which can effectively pass through the blood-brain barrier and help to monitor the decrease of thiol content in the brain.
YANG Y, ZHANG Y, MA M, et al. Synergistic Modulation by Halogens and Pyridine Crossing the Blood–Brain Barrier for In Situ Visualization of Thiol Flux in the Epileptic Brain [J]. Analytical Chemistry, 2022, 94(41): 14443-52. https://doi.org/10.1021/acs.analchem.2c03390.
DT62925016
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5680
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82814
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Common Name：HBTP-H2S chloride
Emission Wavelength：600-700 nm
Fluorophore Types：Cyanine Dyes
Other Types：
CAS No.：N/A
Molecular Weight：603.0900
Formula：C31H27ClN4O5S
Storage：Sealed, in dark
Characteristics：Yellow-green solid
(E)-4-(3-(benzo[d]thiazol-2-yl)-2-(2,4-dinitrophenoxy)-5-methylstyryl)-1-butylpyridin-1-ium chloride
HBTP-H2S ( chloride ) is a near-infrared fluorescent probe for in situ bioimaging of endogenous H2S in rice roots under aluminum stress and waterlogging stress.
WANG J, XIE H, LI H, et al. NIR Fluorescent Probe for In Situ Bioimaging of Endogenous H2S in Rice Roots under Al3+ and Flooding Stresses [J]. Journal of Agricultural and Food Chemistry, 2021, 69(47): 14330-9. https://doi.org/10.1021/acs.jafc.1c05247.
DT62925015
DT62925015-5mg
5mg
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7450
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DT62925015-100mg
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Common Name：NIR-ONOO-
Emission Wavelength：600-700 nm
Fluorophore Types：Cyanine Dyes
Other Types：
CAS No.：N/A
Molecular Weight：680.7365
Formula：C41H34N3O7+
Storage：Sealed, in dark
Characteristics：N/A
(E)-9-(2-carboxyphenyl)-6-(2-(4-nitrophenyl)-2-oxoacetamido)-4-(2-((Z)-1,3,3-trimethylindolin-2-ylidene)ethylidene)-1,2,3,4-tetrahydroxanthylium.
NIR-LAP can sensitively and accurately monitor peroxynitrite ( ONOO- ) ( detection limit : 90 nM ), thereby accurately assessing drug-induced hepatotoxicity.
CHENG D, PENG J, LV Y, et al. De Novo Design of Chemical Stability Near-Infrared Molecular Probes for High-Fidelity Hepatotoxicity Evaluation In Vivo [J]. Journal of the American Chemical Society, 2019, 141(15): 6352-61. https://doi.org/10.1021/jacs.9b01374.
DT62925014
DT62925014-5mg
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Common Name：NIR-LAP
Emission Wavelength：600-700 nm
Fluorophore Types：Cyanine Dyes
Other Types：
CAS No.：N/A
Molecular Weight：616.7815
Formula：C39H42N3O4+
Storage：Sealed, in dark
Characteristics：Blue solid
(E)-6-(2-amino-4-methylpentanamido)-9-(2-carboxyphenyl)-4-(2-((Z)-1,3,3-trimethylindolin-2-ylidene)ethylidene)-1,2,3,4-tetrahydroxanthylium.
NIR-LAP can sensitively and accurately monitor leucine peptidase ( detection limit : 80 mU / L ), thereby accurately assessing drug-induced hepatotoxicity.
CHENG D, PENG J, LV Y, et al. De Novo Design of Chemical Stability Near-Infrared Molecular Probes for High-Fidelity Hepatotoxicity Evaluation In Vivo [J]. Journal of the American Chemical Society, 2019, 141(15): 6352-61. https://doi.org/10.1021/jacs.9b01374.
DT62925013
DT62925013-5mg
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6200
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DT62925013-10mg
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DT62925013-100mg
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100440
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Common Name： IR-990
Emission Wavelength：900-1000 nm
Fluorophore Types：Cyanine Dyes
Other Types：
CAS No.：N/A
Molecular Weight：962.5179
Formula：C48H45BI2N2O3
Storage：Sealed, in dark
Characteristics：Fuchsia solid
1-ethyl-2-((E)-3-((E)-2-(1-methylbenzo[cd]indol-1-ium-2-yl)vinyl)-4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)styryl)benzo[cd]indol-1-ium iodide.
IR-990 was successfully applied to real-time imaging of endogenous H2O2 production in the DILI mouse model, showing a high signal-to-noise ratio of 11.3 / 1. IR-990 has great potential in real-time observation of H2O2 in vivo and revealing the pathogenesi
TIAN Y, LIU S, CAO W, et al. H2O2-Activated NIR-II Fluorescent Probe with a Large Stokes Shift for High-Contrast Imaging in Drug-Induced Liver Injury Mice [J]. Analytical Chemistry, 2022, 94(32): 11321-8. https://doi.org/10.1021/acs.analchem.2c02052.
DT62925012
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6870
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Common Name：GZ22-4
Emission Wavelength：700-800 nm
Fluorophore Types：Cyanine Dyes
Other Types：
CAS No.：N/A
Molecular Weight：1768.1220
Formula：C82H122F3N6NaO23S4
Storage：Sealed, in dark
Characteristics：N/A
sodium 4-((E)-2-((E)-2-(2-(43-((2-(cyclooctylamino)-3,5,6-trifluoro-4-sulfamoylphenyl)sulfonyl)-3,41-dioxo-7,10,13,16,19,22,25,28,31,34,37-undecaoxa-4,40-diazatritetracontyl)-3-((E)-2-(3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-2-yl)vinyl)cyclohex-2-en-1-ylidene)ethylidene)-3,3-dimethylindolin-1-yl)butane-1-sulfonate.
GZ22-4 showed excellent performance in observing CAIX-positive tumors rather than CAIX-negative gene knockout tumors.
ŽVINYS G, PETROSIUTE A, ZAKŠAUSKAS A, et al. High-Affinity NIR-Fluorescent Inhibitors for Tumor Imaging via Carbonic Anhydrase IX [J]. Bioconjugate Chemistry, 2024, 35(6): 790-803. https://doi.org/10.1021/acs.bioconjchem.4c00144.
DT62925011
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8800
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142560
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Common Name：TME-HYM (PH Probe)
Emission Wavelength：600-700 nm
Fluorophore Types：Cyanine Dyes
Other Types：
CAS No.：N/A
Molecular Weight：782.5089
Formula：C35H36I2N4O
Storage：Sealed, in dark
Characteristics：Orange-red solid
(E)-7-iodo-1,1,3-trimethyl-2-(2-(1-methyl-9-(2-morpholinoethyl)-9H-pyrido[3,4-b]indol-3-yl)vinyl)-1H-benzo[e]indol-3-ium iodide.
TME-HYM is a new fluorescent probe based on the activation of acidic tumor microenvironment. TME-HYM ( PH Probe ) can selectively light cancer cells and tumor tissues. It has dual tumor selectivity and can accurately display tumor masses. HYM can achieve
XU Z, TAO W, QIAN J, et al. Dual Tumor-Selective β-Carboline-Based Fluorescent Probe for High-Contrast/Rapid Diagnosis of Clinical Tumor Tissues [J]. Molecular Pharmaceutics, 2024, 21(1): 152-63. https://doi.org/10.1021/acs.molpharmaceut.3c00689.
DT62925010
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Common Name：LE 28
Emission Wavelength：600-700 nm
Fluorophore Types：Cyanine Dyes
Other Types：
CAS No.：1416080-97-1
Molecular Weight：1909.2385
Formula：C102H111N10O21S3+
Storage：Sealed, in dark
Characteristics：Blue powder
1-(6-((4-carboxy-1-(2-((1-carboxy-4-((4-((3-(1-((2-(3,6-di(indolin-1-yl)xanthylium-9-yl)phenyl)sulfonyl)piperidine-4-carboxamido)propyl)carbamoyl)-2,6-dimethylbenzoyl)oxy)-3-oxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxobutan-2-yl)amino)-6-oxohexyl)-2-((1E,3E)-5-((Z)-1-ethyl-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-5-sulfonate.
The LE 28 probe is highly selective for legumain, and legumain is found to be highly correlated with macrophage activation by LE 28 probe, and it is an ideal marker for primary tumor inflammation and early metastatic lesions.
EDGINGTON L E, VERDOES M, ORTEGA A, et al. Functional Imaging of Legumain in Cancer Using a New Quenched Activity-Based Probe [J]. Journal of the American Chemical Society, 2013, 135(1): 174-82. https://doi.org/10.1021/ja307083b.
DT6230971
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Common Name：MOR-CES2
Emission Wavelength：700-800 nm
Fluorophore Types：Cyanine Dyes
Other Types：
CAS No.：2956672-93-6
Molecular Weight：603.4565
Formula： C31H26INO4
Storage：Sealed, in dark
Characteristics：Purple solid
(E)-2-(2-(6-(benzoyloxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-3-ethylbenzo[d]oxazol-3-ium iodide.
MOR-CES2 is a near-infrared fluorescent probe that can recognize cancer cells and tissues and is sensitive to inflammatory responses. MOR-CES2 acts as an effective imaging tool in the surgical resection of CES2-related tumors.
WANG X, GAO J, FAN C, et al. New Near-Infrared Fluorescence Imaging Platform with Large Stokes Shift for Carboxylesterase 2 Detection in Thyroid Cancer and Inflammatory Diseases Diagnosis [J]. Analytical Chemistry, 2024, 96(9): 3772-9. https://doi.org/10.1021/acs.analchem.3c04399.
DT6232936
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Common Name：CYP1B1-IN-6
Emission Wavelength：600-700 nm
Fluorophore Types：Cyanine Dyes
Other Types：
CAS No.：N/A
Molecular Weight：1470.6264
Formula：C71H76FN3O22S4
Storage：Sealed, in dark
Characteristics：Blue solid
2-((1E,3E,5E)-5-(3-ethyl-1,1-dimethyl-6,8-disulfo-1,3-dihydro-2H-benzo[e]indol-2-ylidene)penta-1,3-dien-1-yl)-3-(1-(3-fluoro-5-(6,7,10-trimethoxy-4-oxo-4H-benzo[h]chromen-2-yl)phenoxy)-13-oxo-3,6,9-trioxa-12-azaoctadecan-18-yl)-1,1-dimethyl-8-sulfo-1H-benzo[e]indol-3-ium-6-sulfonate.
CYP1B1-IN-6 is a fluorescent probe that can inhibit the activity of CYP1B1 and can be enriched in tumor cells by binding to CYP1B1. CYP1B1-IN-6 can identify tumor sites in fluorescence imaging and photoacoustic imaging modes.
CHEN D, LI R, SHAO Q, et al. Design and Synthesis of Novel Near-Infrared Fluorescence Probes Based on an Open Conformation of a Cytochrome P450 1B1 Complex for Molecular Imaging of Colorectal Tumors [J]. Journal of Medicinal Chemistry, 2023, 66(23): 16032-50. https://doi.org/10.1021/acs.jmedchem.3c01474.
DT62925009
DT62925009-5mg
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DT62925009-100mg
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174960
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Common Name：HS-131
Emission Wavelength：600-700 nm
Fluorophore Types：Cyanine Dyes
Other Types：
CAS No.：2084850-40-6
Molecular Weight：1317.6895
Formula：C71H94N7O13S2-
Storage：Sealed, in dark
Characteristics：N/A
3H-Indolium,2-[(1E,3Z,5E)-3-[4-[21-[[2-(aminocarbonyl)-5-(4,5,6,7-tetrahydro-3,6,6-trimethyl-4-oxo-1H-indazol-1-yl)phenyl]amino]-6,9,12,15,18-pentaoxa-Chemicalbook2-azaheneicos-1-yl]phenyl]-5-[1,3-dihydro-3,3-dimethyl-1-(4-sulfobutyl)-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-3,3-dimethyl-1-(4-sulfobutyl)-,innersalt.
HS-131 is a near-infrared Hsp90 dye inhibitor that is sensitive and specific to all molecular subtypes of mouse and human breast cancer, and has a high uptake rate in invasive and highly metastatic clones.
OSADA T, KANEKO K, GWIN W R, et al. In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior [J]. Clin Cancer Res, 2017, 23(24): 7531-42. DOI: 10.1158/1078-0432.CCR-17-1453.
DT6230406
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DT6230406-100mg
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174960
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Common Name：BiHCy-HClO
Emission Wavelength：700-800 nm
Fluorophore Types：Xanthene Derivatives
Other Types：
CAS No.：N/A
Molecular Weight：1041.12
Formula： C51H61IN8O4S2
Storage：Sealed, in dark
Characteristics：Blue black powder
2-((E)-2-(6-((dimethylcarbamothioyl)oxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-1,1-dimethyl-3-(4-(1-(3-(5-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)propyl)-1H-1,2,3-triazol-4-yl)butyl)-1H-benzo[e]indol-3-ium iodide.
BiHCy HClO is a near-infrared fluorescent dye.
N/A
DT62925008
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Common Name：BiHCy-H2O2
Emission Wavelength：700-800 nm
Fluorophore Types：Xanthene Derivatives
Other Types：
CAS No.：N/A
Molecular Weight：1170.07
Formula：C61H73BIN7O6S
Storage：Sealed, in dark
Characteristics：Blue black powder
1,1-dimethyl-3-(4-(1-(3-(5-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)propyl)-1H-1,2,3-triazol-4-yl)butyl)-2-((E)-2-(6-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)-2,3-dihydro-1H-xanthen-4-yl)vinyl)-1H-benzo[e]indol-3-ium iodide.
BiHCy H2O2 is a near-infrared fluorescent dye.
N/A
DT62925007
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DT62925007-100mg
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Common Name：NOx-JS013
Emission Wavelength：600-700 nm
Fluorophore Types：BODIPY
Other Types：
CAS No.：N/A
Molecular Weight：1071.04
Formula：C62H65BF2N6O8
Storage：Sealed, in dark
Characteristics：Green powder
4-(5,5-difluoro-7-(4-(2-((2-(2-(2-(4-(2-(((2-isopropylphenoxy)carbonyl)amino)ethyl)phenoxy)ethoxy)ethoxy)ethyl)amino)-2-oxoethoxy)phenyl)-1,9-diphenyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2',1'-f][1,3,5,2]triazaborinin-3-yl)-N,N-diethylaniline oxide.
NOx-JS013 is a near-infrared fluorescent dye.
SONG J., ZHAI T., HAHM H. S., et al. Development of a Dual-Factor Activatable Covalent Targeted Photoacoustic Imaging Probe for Tumor Imaging [J]. Angew. Chem. Int. Ed., 2024, 63(40): e202410645.
DT62925004
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DT62925004-100mg
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Common Name：ICG-PEG-Folate
Emission Wavelength：800-900 nm
Fluorophore Types：Cyanine Dyes
Other Types：
CAS No.：N/A
Molecular Weight：1176.41
Formula：C68H75N10O9+
Storage：Sealed, in dark
Characteristics：Green powder
2-((1E,3E,5E,7E)-7-(3-(1-(4-(((7-amino-5-oxo-5,6-dihydropyrido[3,4-b]pyrazin-3-yl)methyl)amino)phenyl)-3-carboxy-1,6,14-trioxo-10-oxa-2,7,13-triazahexadecan-16-yl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)hepta-1,3,5-trien-1-yl)-3-(5-carboxypentyl)-1,1-dimethyl-1H-benzo[e]indol-3-ium.
ICG PEG Fluoride is a near-infrared fluorescent dye that can target folate receptors.
CHEN S., ZHU L., DU Z., et al. Polymer encapsulated clinical ICG nanoparticles for enhanced photothermal therapy and NIR fluorescence imaging in cervical cancer [J]. RSC Advances, 2021, 11(34): 20850-20858.
DT62925003
DT62925003-5mg
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710
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1278
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100mg
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11502
10352
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Common Name：ICG-PSMA
Emission Wavelength：800-900 nm
Fluorophore Types：Cyanine Dyes
Other Types：
CAS No.：N/A
Molecular Weight：1046.29
Formula：C58H71N5O11S
Storage：Sealed, in dark
Characteristics：Green powder
4-(2-((1E,3E,5E,7E)-7-(3-(6-(((S)-5-carboxy-5-(3-((R)-1,4-dicarboxybutan-2-yl)ureido)pentyl)amino)-6-oxohexyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)hepta-1,3,5-trien-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-3-yl)butane-1-sulfonate.
ICG-PSMA is a near-infrared fluorescent dye that can be used for fluorescence imaging diagnosis of prostate cancer.
CHEN S., ZHU L., DU Z., et al. Polymer encapsulated clinical ICG nanoparticles for enhanced photothermal therapy and NIR fluorescence imaging in cervical cancer [J]. RSC Advances, 2021, 11(34): 20850-20858.
DT62925002
DT62925002-5mg
5mg
95%
1660
1494
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DT62925002-10mg
10mg
95%
2988
2689
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DT62925002-100mg
100mg
95%
26890
24202
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Common Name：ICG Biotin
Emission Wavelength：800-900 nm
Fluorophore Types：Cyanine Dyes
Other Types：
CAS No.：N/A
Molecular Weight：999.34
Formula：C57H70N6O6S2
Storage：Sealed, in dark
Characteristics：Solid powder
4-(2-((1E,3E,5E,7E)-7-(1,1-dimethyl-3-(6-oxo-6-((2-(5-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethyl)amino)hexyl)-1,3-dihydro-2H-benzo[e]indol-2-ylidene)hepta-1,3,5-trien-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-3-yl)butane-1-sulfonateMolecular Weight: 999.3430.
ICG Biotin is a near-infrared fluorescent dye that can target biotin receptors.
KOZMA E., KELE P. Bioorthogonal Reactions in Bioimaging [J]. Top. Curr. Chem., 2024, 382(1): 7.
DT62925001
DT62925001-5mg
5mg
95%
1560
1404
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DT62925001-10mg
10mg
95%
2808
2527
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DT62925001-100mg
100mg
95%
25272
22745
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